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EPISTEM European Project to guide and investigate the potential for - PowerPoint PPT Presentation

May 21, 2023 •195 likes •293 views

EPISTEM European Project to guide and investigate the potential for HIV cure by Stem Cell Transplantation. www.epistem-project.org EPISTEM Project to guide and investigate the potential for HIV cure in HIV-infected patients requiring

  1. EPISTEM European Project to guide and investigate the potential for HIV cure by Stem Cell Transplantation. www.epistem-project.org

  2. EPISTEM Project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders Supported by AmfAR Research Consortium on HIV eradication (ARCHE) Research Grant # 108930-56-RGRL

  3. Investigators Scientific Investigators: Javier Martinez-Picado (PI) and Annemarie Wensing (PI), Monique Nijhuis, Gero Hütter, Jan van Lunzen, Vanderson Rocha Clinical Investigators: Jürgen Kuball, Jose Luis Diez Martin

  4. What does EPISTEM provide? Clinical, Pharmacological and Ethical Guidance Panel Experts in by multidisciplinary video calls, by provision of protocols Hematology Donor search and CCR5 host Infectious Diseases testing Virology Detailed Sampling Protocol Immunology Ultra-sensitive virological and Pharmacology immunological assays qpcr, digital droplet pcr, single copy, viral outgrow, in depht phenotypic and genotypic tropism characterisation, B/T cell assays, innate immunity, subset analyses and others

  5. AIM To prospectively study allogeneic SCT recipients with HIV-1 infection, collecting complete information on underlying malignancy, chemotherapy, transplant procedure, donor selection, HIV-tropism, cART, and samples to be stored before and after the transplant.

  6. AIM To systematically study recipient samples for (i) multiple complementary quantifications of the viral reservoirs, (ii) molecular and functional characterization of infecting virus, and (iii) immunological determinations during the multiple phases of an allogeneic SCT, which might help to understand the biological bases of a potential new case of HIV-1 cure.

  7. Organisation Currently 11 patients included

  8. If you have an HIV infected patient who need a SCT please Contact Mrs. Antoinet van Kessel/ Drs. Karin Siebelt A.vankessel-4@umcutrecht.nl or K.G.Siebelt@umcutrecht.nl +31 88 7556526 www.epistem-project.org The EPISTEM project is supported by AmfAR Research Consortium on HIV eradication (ARCHE) Research Grant # 108930-56-RGRL

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