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Discovering New Drug-Drug Interactions By Text-Mining the Biomedical Literature Beth Percha CS 224N Final Project March 17, 2011 Background Americans are on a lot of drugs. Drug interactions are bad. We don't test for them in

  1. Discovering New Drug-Drug Interactions By Text-Mining the Biomedical Literature Beth Percha CS 224N Final Project March 17, 2011

  2. Background ● Americans are on a lot of drugs. ● Drug interactions are bad. ● We don't test for them in clinical trials. ● We need ways to find likely interactions so we can watch out for them.

  3. Methods (I) Start with indexed version of Medline: Two lexicons: 17 million abstracts Genes (43 VIP genes) AND 88 million sentences Drugs (602; at least one interaction)

  4. Methods (II)

  5. Results (I)

  6. Results (II) Least likely interactions... Most likely interactions...

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