Cynata Corporate Presentation Melbourne, Australia; 30 October 2019: - PDF document

ASX ANNOUNCEMENT 30 October 2019 Cynata Corporate Presentation Melbourne, Australia; 30 October 2019: Australian stem cell and regenerative medicine company, Cynata Therapeutics Limited (ASX: CYP), today released a presentation Cynata CEO, Dr Ross Macdonald, will use with investors to update on recent progress and public announcements. -EN ENDS- CONTACTS: Dr Ross Macdonald, CEO, Cynata Therapeutics, +61 (0)412 119343, ross.macdonald@cynata.com Claire LaCagnina, U.S. Media Contact, +1 315.765.1462, clacagnina@6degreespr.com Ab About C Cynata T Thera rapeutics ( (ASX: X: C CYP) Cynata Therapeutics Limited (ASX: CYP) is an Australian clinical-stage stem cell and regenerative medicine company focused on the development of therapies based on Cymerus™, a proprietary therapeutic stem cell platform technology. Cymerus overcomes the challenges of other production methods by using induced pluripotent stem cells (iPSCs) and a precursor cell known as mesenchymoangioblast (MCA) to achieve economic manufacture of cell therapy products, including mesenchymal stem cells (MSCs), at commercial scale without the limitation of multiple donors. Cynata’s lead product candidate CYP-001 met all clinical endpoints and demonstrated positive safety and efficacy data for the treatment of steroid-resistant acute graft-versus-host disease (GvHD) in a Phase 1 trial. Cynata plans to advance its Cymerus™ MSCs into Phase 2 trials for GvHD, critical limb ischemia and osteoarthritis. In addition, Cynata has demonstrated utility of its Cymerus MSC technology in preclinical models of asthma, diabetic wounds, heart attack and cytokine release syndrome, a life-threatening condition stemming from cancer immunotherapy. Cynata Therapeutics Limited Level 3, 62 Lygon Street, Carlton, Victoria 3053, Australia PO Box 7165, Hawthorn North, Victoria 3122 T: + 613 9824 5254 F: + 613 9822 7735 E: info@cynata.com ABN - 98 104 037 372

A Next Generation Stem Cell Therapeutics Company Investor Presentation: Cynata Therapeutics Limited October 2019

Important Information This presentation has been prepared by Cynata Therapeutics Limited. (“Cynata” or the “Company”) based on information available to it as at the date of this presentation. The information in this presentation is provided in summary form and does not contain all information necessary to make an investment decision. This presentation does not constitute an offer, invitation, solicitation or recommendation with respect to the purchase or sale of any security in Cynata, nor does it constitute financial product advice or take into account any individual’s investment objectives, taxation situation, financial situation or needs. An investor must not act on the basis of any matter contained in this presentation but must make its own assessment of Cynata Therapeutics and conduct its own investigations. Before making an investment decision, investors should consider the appropriateness of the information having regard to their own objectives, financial situation and needs, and seek legal, taxation and financial advice appropriate to their jurisdiction and circumstances. Cynata Therapeutics is not licensed to provide financial product advice in respect of its securities or any other financial products. Cooling off rights do not apply to the acquisition of Cynata Therapeutics securities. Although reasonable care has been taken to ensure that the facts stated in this presentation are accurate and that the opinions expressed are fair and reasonable, no representation or warranty, express or implied, is made as to the fairness, accuracy, completeness or correctness of the information, opinions and conclusions contained in this presentation. To the maximum extent permitted by law, none of Cynata Therapeutics, its officers, directors, employees and agents, nor any other person, accepts any responsibility and liability for the content of this presentation including, without limitation, any liability arising from fault or negligence, for any loss arising from the use of or reliance on any of the information contained in this presentation or otherwise arising in connection with it. The information presented in this presentation is subject to change without notice and Cynata Therapeutics does not have any responsibility or obligation to inform you of any matter arising or coming to their notice, after the date of this presentation, which may affect any matter referred to in this presentation. The distribution of this presentation may be restricted by law and you should observe any such restrictions. Forward looking statements This presentation contains certain forward looking statements that are based on the Company’s management’s beliefs, assumptions and expectations and on information currently available to management. Such forward looking statements involve known and unknown risks, uncertainties, and other factors which may cause the actual results or performance of Cynata to be materially different from the results or performance expressed or implied by such forward looking statements. Such forward looking statements are based on numerous assumptions regarding the Company’s present and future business strategies and the political and economic environment in which Cynata will operate in the future, which are subject to change without notice. Past performance is not necessarily a guide to future performance and no representation or warranty is made as to the likelihood of achievement or reasonableness of any forward looking statements or other forecast. To the full extent permitted by law, Cynata and its directors, officers, employees, advisers, agents and intermediaries disclaim any obligation or undertaking to release any updates or revisions to information to reflect any change in any of the information contained in this presentation (including, but not limited to, any assumptions or expectations set out in the presentation). www.cynata.com 2

Cynata Therapeutics is a Phase II-ready biotech with a highly scalable, proprietary platform for developing stem cell therapeutics Our focus Financial information Utilise our proprietary Cymerus TM platform Share price (28-Oct-19) A$1.32 technology to develop commercially scalable Shares on issue 102.8m cellular therapeutic products to treat serious A$135.7m chronic disorders Market capitalisation 1 ~(US$92.8m) About Cynata Therapeutics Cash 2 A$9.2m Debt -  Cynata is an Australian stem cell and regenerative medicine company that is developing a therapeutic Enterprise value A$126.5m stem cell platform technology, Cymerus, using discoveries made at the University of Wisconsin- Madison Top shareholders  Cynata has licensed its first product, CYP-001 for graft-versus-host-disease (GvHD) to Fujifilm, with 9.3% the intention to license Cymerus technology across a range of serious disorders  Cynata’s proprietary Cymerus technology addresses 7.9% a critical shortcoming in existing methods of production of mesenchymal stem cells (MSCs) for therapeutic use, which is the ability to achieve Board and management 6.0% economic manufacture at commercial scale www.cynata.com 1. USD/AUD = 1.46; 2. Cash balance as at 30-Sep-19 of A$9.2m 3

2019 Highlights: Driving Clinical and Commercial Success Phase I se II GvH vHD t D trial Progres essi sing O Osteo eoarthritis    Fujifilm l licen ense se fund unded ed by by F Fujifilm to Ph o Phase I II tria ial  Fujifilm to fund CYP-001  Advancing towards 448 patient  Fujifilm exercised license option for development and commercialisation Phase I clinical trial CYP-001 in (GvHD) with a Phase II clinical trial expected  Funded by the National Health and  Future development of CYP-001 being to commence in CY2020 Medical Research Council funded entirely by Fujifilm  US$3m upfront payment to Cynata + milestones + royalties Fujifilm endorsement validates Cynata’s Phase II trial expected to commence in Phase II trial expected to commence in Cymerus platform CY2020 Q1 CY2020 Prog Pr ogressin ing C CLI to o Advanc nced p d pre-clinical Active c e commer ercial    Phase I se II trial progra ram disc scussi ssions  Critical Limb Ischaemia (CLI): major  Cymerus platform has therapeutic  Executing on the Company’s clinical challenge and unmet need potential in numerous additional commercial plan to unlock the value of target areas of chronic disease  Severely impaired blood flow in the its platform technology across a broad arteries: typically legs  Multiple preclinical studies range of indications successfully completed and data  Clinical Trial Authorisation published application filing expected imminently Phase II trial expected to commence in Therapeutic potential in numerous Focus on early commercialisation of early CY2020 additional target areas Cynata’s Cymerus MSC products www.cynata.com 4