Cur r e nt T r e nds in Can you find out De te c table Dr ugs - PDF document

21/09/2012 Cur r e nt T r e nds in Can you find out De te c table Dr ugs what dr ugs the patie nt has take n? Pe te r Bowr on T oxic ology Unit - PaL MS Dr ug Analysis PaL MS T e sting • Rapid T • Appr e sts oximate ly 130,000 • AS 4308 • Half “T ar ge te d” • Routine Clinic al • Half “Br oad te sting” • Br oad Base d T e c hnique s HPT L C • Immunoassays • HPT L C • T ar ge te d GC/ MS • Br oad Sc r e e n GC/ MS 1

21/09/2012 Morphine MethAmp Data L imitations 9000 8000 • Pe r 7000 sample not patie nt 6000 • Diffe r e nt c linic pr otoc ols 5000 4000 • L ong half-life vs. shor t 3000 2000 • What’s on the list? 1000 0 • How muc h is pr e sc r ibe d? 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Nitrazepam “Sle e ping Pills” 180 160 • Bar bitur ate s 140 120 • Me thaqualone 100 80 • Be nzodiaze pine s 60 40 • Mor e Be nzodiaze pine s 20 • Z-Dr ugs 0 1998 2000 2002 2004 2006 2008 2010 2012 Flunitrazepam Clonazepam 350 800 300 700 600 250 500 200 400 150 300 100 200 50 100 0 0 1998 2000 2002 2004 2006 2008 2010 2012 1998 2000 2002 2004 2006 2008 2010 2012 2

21/09/2012 Alprazolam Nitrazepam Flunitrazepam Clonazepam Alprazolam 1400 1400 1200 1200 1000 1000 800 800 600 600 400 400 200 200 0 0 1998 2000 2002 2004 2006 2008 2010 2012 1998 2000 2002 2004 2006 2008 2010 2012 Pr isons 11-12 Dr ugs in Pr isons 1200 1000 800 600 1427 Illic it 400 T he r ape utic 2014 200 0 Que t Ca n Bup taz MA az Oxaz Morph Mdn Clonaz Alpr Mir Mirtazepine Quetiapine 1800 1200 1600 1000 1400 1200 800 1000 600 800 600 400 400 200 200 0 0 1998 2000 2002 2004 2006 2008 2010 2012 1998 2000 2002 2004 2006 2008 2010 2012 3

21/09/2012 Oxycodone 500 450 400 350 300 What ar e we 250 200 missing? 150 100 50 0 1998 2000 2002 2004 2006 2008 2010 2012 Spe c ial T e sts Challe nge s • Ke tamine • L SD • F • Ste r e ntanyl oids • Bupr • Spic e e nor phine • De signe r Amphe tamine s 4