Contact: Sjaak Deckers, CEO +316 2249 0104 - PowerPoint PPT Presentation

Introduction Oct 2018 Contact: Sjaak Deckers, CEO +316 2249 0104 sjaak.deckers@gtxmedical.com 2018 Oct 20 Confidential 2017 Dec 21 Slide 1

The Spinal Cord Injury Iceberg Wheelchair Heart rate Pressure ulcers Blood pressure (hypo) Sleep Transpiration Infections Thermoregulation Antibiotics use Bladder physiology Bone density Bowel physiology Muscle mass Sexual function Spasticity Cardiovascular cap. Pain Dependence on others Hours daily routine Limitations in jobs, activities with kids, weekend activities, travel, etc 2018 Oct 20 Confidential 2017 Dec 21 Slide 2

400’000 spinal cord injuries every year Photo: Herb Ritts Single patient lifetime healthcare cost is above 2 m$ 2018 Oct 20 Confidential 2017 Dec 21 Slide 3

GTX medical Lausanne and Eindhoven ▪ Strong IP & licensing position ▪ Spin-off of research group at EPFL ▪ Strong Investor support & solid financing (April 2016) ▪ T eam started in 2016, now 40 employees ▪ Initial focus: paraplegic incomplete SCI patients ▪ Lausan anne ne, Switze zerla rland Eindhov oven, n, The Netherlan lands 2018 Feb 14 2018 Oct 20 Confidential 2017 Dec 21 Slide 4

Current: Lifelong severe disability Les esio ion Car are e an and d reh ehab ab Live e with th the e di disab ability ility ▪ Traffic accident ▪ Training ▪ Falls ▪ Learning to perform tasks ▪ Bleeding ▪ Achieving best quality of life 2018 Oct 18 2018 Oct 20 Confidential 2017 Dec 21 Slide 5

GTX medical neuroprosthetic therapy (under development) Lesio ion Spi pinal al Cord d Surge gery Intensive ensive rehab b training ning Restor ored ed fu function tion ▪ Traffic accident ▪ Place epidural lead + ▪ Initial mapping phase Unsupervised use at ▪ ▪ Falls pulse generator ▪ 5mo, 5x/wk, 2h/d BWS home ▪ Bleeding ▪ T est muscle responses training to promote neuroplasticity 2018 Oct 18 2018 Oct 20 Confidential 2017 Dec 21 Slide 6

Based upon solid scientific understanding Breakthroughs Prof Courtine, EPFL Nature 2018, 2016 Science 2015, 2012 Neuron 2016, 2015 Science Trans Med 2017, 2015, 2014 Nature Medicine 2016, 2012, 2008, 2007 Nature Neuroscience 2018, 2010, 2009 Cell 2014 The Lancet 2011 2018 Oct 20 Confidential 2017 Dec 21 Slide 7

THE SPINAL CORD IS NOT ITS SERVANT 2018 Oct 20 2018 Feb 14 Confidential 2017 Dec 21 Slide 8

Developing a new therapy Rehabilitation clinicians, Physiotherapists, Technician Neurologist Electrophysiologist, Technician Neurosurgeon Beyond Implantation Mapping Rehabilitation Rehabilitation Functional mapping: Rehab with BWS - define stimulation functional outcome. Rehab without BWS - define stimulation configurations and Home Training + Home Use in daily life activities training programs. GTX medical 2018 Oct 20 2018 Feb 14 Confidential 2017 Dec 21 Slide 9

Intensive body weight supported training activates neuroplasticity Rysen 3D 3D overgrou ound Body Weight Support system for flexible rehab training. Partnering with MOTEK (Amst sterdam) am) 2018 Oct 20 2018 Feb 14 Confidential 2017 Dec 21 Slide 10

Implantation surgery of lead and INS STIMO STIMO Cervical Thoracic The electrode array is inserted via incision L1-L2 Lumbar Sacral The stimulator is implanted in the belly 2018 Oct 20 2018 Feb 14 Confidential 2017 Dec 21 Slide 11

Stimulating at the right time & place (Courtine, Nature 2018) Muscle activi vity during gait cycle in healthy persons Corresp spon ondin ing electrical rical recordin ings Neuromotor otor hotspot ots s Muscle activi vity in SCI patient Muscle activi vity using stimulat lation ion Stimulation lation: 2018 Oct 20 2018 Feb 14 Confidential 2017 Dec 21 Slide 12

Simulations predict muscle mappings (Courtine, Nature 2018) Muscle mappings and stimula lation ion pattern rns s in healthy person ons Individu idualise alised simulati ation ons s predict simila lar stimulat lation ion pattern rns s Targeted stimulat lation ion can separa rate between left hip flexi xion on and left ankle extension ion 2018 Oct 20 2018 Feb 14 Confidential 2017 Dec 21 Slide 13

Thank you 2018 Oct 20 Confidential 2017 Dec 21 Slide 14