Cloud-Based Drug Design and Development Cavendish Global Health Impact Forum October 25-28, 2015 www.cloudpharmaceuticals.com
Pancreatic Cancer Key statistics for 2015 from the American Cancer Society: 50,000 3% People diagnosed Of all cancers in the US 40,560 7% Will die from Of all cancer deaths pancreatic cancer in the US Source: American Cancer Society, Inc.
Finding a Cure Uses genome data and DNA analysis Targets pancreatic cancer to discover novel drug targets using real genomics data Designing drug leads for those targets
Central Nervous System Diseases Alzheimer’s 50,000 2/3 6th Americans have it Are women leading cause of death Only cause of death in the top 10 in America that can't be prevented, slowed, or cured Amyotrophic Lateral Sclerosis Progressive degeneration of Does not impair your Impairs voluntarily and Often results in Considered by NIH motor nerve cells in the intellect or senses involuntary muscles respiratory failure as orphan disease brain and spinal cord Source: Alzheimer’s Association Source: The Johns Hopkins University
Finding a Cure AI technology identifies novel targets by souring published research enabling basket trials Designs drug leads for those targets and filters for drug properties such as blood – brain barrier
Virtual Molecular Space Contains every small molecule to increase the wellness of people around the world, to prevent people from dying, and to relieve their pain and suffering The trick is to find the right ones
Our Mission Improve health Design small Apply cloud and well-being through the molecules that drug computing and rapid and efficient design of novel targets produced computational chemistry new medicines by pathologies to design drugs Pre-qualified candidates enable us to reduce cost, accelerate development, and target elusive indications
The Time is Now for In Silico Why? Moore's Law • Accessibility of cloud-based super computing • • Artificial intelligence How? • Store 3D model of every human protein in the druggable genome • Analyze a proposed drug for toxicity prior to clinical trial Emerging life sciences data center
Valuable Relationships Collaboration developing Muscle growth Paid proof of concept 12 drugs, validation data and inflammation research Collaboration developing Autism and cancer research 7 drug programs Malaria collaboration Grant for development of discovery methods and Drug discovery platform to model select drugs and analyze druggable genome
How Do We Develop Medicines for Challenging Diseases? Identify the molecules with outstanding drug-like properties that modulate the activity of protein targets Apply Partner Harness the right technology with visionary companies the trends of the digital revolution
Questions? Ed Addison, CEO Cloud Pharmaceuticals Inc. 6 Davis Drive Research Triangle Park, NC 27709 (910) 398-1200 ed.addison@cloudpharmaceuticals.com www.cloudpharmaceuticals.com
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