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Caring for Babies Thinking of Families Sean Loudin, MD FAAP NAS is a Key to the Substance Abuse Epidemic NAS Representative Population Identified at risk population Mothers are fundamental to family stability Brain Development


  1. Caring for Babies Thinking of Families Sean Loudin, MD FAAP

  2. NAS is a Key to the Substance Abuse Epidemic NAS • Representative Population • Identified at risk population • Mothers are fundamental to family stability

  3. Brain Development

  4. Pathogenesis of NAS Alternative Pathway Disuse Hypersensitivity

  5. NAS Births per 1000 at CHH

  6. Patients Treated for with Methadone for NAS per 1000 Births at CHH Year 2010 2011 2012 2013 2014 2015 Live Births 2436 2494 2641 2801 2755 2810 Prenatal Exposures 71 79 111 459 547 522 NAS per 1000 29.1 31.7 42.0 163.9 198.5 185.8 Pharmacologically Treated NAS 83 102 135 214 224 265 Treated NAS per 1000 34.1 40.9 51.1 76.4 81.3 94.3 %multi-Substance 46% 47% 58% 54% 52% 53%

  7. Estimates of Total OUD using NAS Births as a Representative Sample Range Estimates for Opioid Use Disorder Using NAS Data Nationally Available Data Local Data 0.0% 5.0% 10.0% 15.0% 20.0% 25.0%

  8. Places For Treatment

  9. Distribution of NAS Patients Admitted to Individual Treatment Units 100% 90% 80% 70% NAS Patients 60% Lily's Place 50% NTU 40% NICU 30% 20% 10% 0% 2011 2012 2013 2014 2015

  10. Estimated Charge Avoidance Using Specialized Treatment Units

  11. Mothers Need Treatment Pregnant and early post-partum women need about 12 weeks of intensive outpatient therapy for initial recovery stabilization P E 5 0 P E 8 0 P E 9 0 1 0 0 P e rc e n t C o m p lia n t 5 0 0 0 5 1 0 1 5 2 0 3 0 W e e k

  12. Mothers Impact NAS Treatment of Neonates Born to Treatment of Neonates Born Mothers with to Mothers with Proportion of neonates standardized for Methadone Major Depressive Disorder Panic Disorder 7 4.5 Proportion of neonates standardized for Methadone 4 6 3.5 5 3 treatment 4 2.5 2 3 treatment 1.5 2 1 1 0.5 0 0 No Treatment Methadone Methadone + No Treatment Methadone Methadone + Adjunctive Adjunctive No MDD MDD No Panic Disorder Panic Disorder

  13. Mothers Impact NAS Treatment of Neonates Born to Mothers with Post Partum Depression 8 Proportion of neonates standardized for Methadone treatment 7 6 5 4 3 2 1 0 No Treatment Methadone Methadone + Adjunctive No PPD PPD

  14. Mom’s are Fundamental to Family Stability Average Per Patient Charges for Baby’s First Year Following MAT Enrollment During Pregnancy $1,552,13 $453.75 Not Enrolled Enrolled

  15. Thank You

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