Anthelmintic resistance in Europe Cattle, sheep and horses - PowerPoint PPT Presentation

Apr 23, 2023 •281 likes •450 views

Anthelmintic resistance in Europe Cattle, sheep and horses Presented by Anita Bottger on 13 June 2016 EWP member, CBG-MEB An agency of the European Union Contents Overview of the anthelmintic resistance situation in Europe - Cattle -

Anthelmintic resistance in Europe Cattle, sheep and horses Presented by Anita Bottger on 13 June 2016 EWP member, CBG-MEB An agency of the European Union
Contents Overview of the anthelmintic resistance situation in Europe - Cattle - Horses - Sheep 1 Anthelmintic resistance in Europe
Source : De Graeve Vlaams Diergeneeskundig Tijdschrift 2012 2 Anthelmintic resistance in Europe
Cattle 3 Anthelmintic resistance in Europe
Resistance Cooperia oncophora Ostertagia ostertagi Typical nodules in abomasum: hyperplasia and distention of gastric glands 4 Anthelmintic resistance in Europe
Ivermectin resistance In 2006 Cooperia oncophora n= 6 and/ or Ostertagia ostertagi source Demeler et al 2008 Reduced efficacy (FECR< 95% on day 21) Belgium 5/ 7 farms* Sweden 4/ 5 farms Germany 5/ 8 farms* * lower CI< 90% in all farms n= 9 n= 7
Monitoring resistance development . one farm Source El Abdellati et al (2010) FECRT Cooperia oncophora Ivermectin resistance
Horses 7 Anthelmintic resistance in Europe
Resistance in Europe Parascaris equorum Cyathostominae -ivermectin (reports -Benzimidazoles frequent throughout Europe) -pyrantel (some reports) -moxidectin (reports) -ivermectin/ moxidectin? Source: Von Samson-Himmelstjerna, 2011, Nielsen 2014, Matthews 2014 8 Anthelmintic resistance in Europe
Sheep 9 Anthelmintic resistance in Europe
Resistant helminths - Teladorsagia spp, - Haemonchus contortus, - Trichostrongylus spp - Fasciola hepatica 10 Anthelmintic resistance in Europe
Resistance in sheep helminths in Europe - Benzimidazoles - Levamisole Increased resistance to macrocyclic lactones - Ivermectin (mainly) - Doramectin - Moxidectin - Multi-drug resistant helminths - Triclabendazole (flukicide) - Source Papadopoulos 2012 11 Anthelmintic resistance in Europe
Triclabendazole resistance in Fasciola hepatica in the Netherlands. Based on necropsy and FECRT Monitoring is voluntary: underestimation Source V.d. Brom, GD Deventer
conclusion - Resistance can spread very quickly within a wormpopulation - Reports on resistance situation used small numbers of farms - Monitoring program in entire Europe? 13 Anthelmintic resistance in Europe
Thank you for your attention European Medicines Agency 30 Churchill Place • Canary Wharf • London E14 5EU • United Kingdom Telephone + 44 (0)20 3660 6000 Facsim ile + 44 (0)20 3660 5555 Send a question via our w ebsite www.ema.europa.eu/ contact Follow us on @EMA_ New s

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