World Dementia Council Leading the Global Action Against Dementia A Global Response to the � Global Challenge of Dementia Yves Joanette, PhD, FCAHS Chair, World Dementia Council
Populations are getting older
Populations are getting older
% of Growth of Population 2005-2030 Prevalence of Dementia Approx. 6-8 % Approx. 30-35 % Source Alzheimer Society Canada, 2016 Source: United Na0ons Department of Economic and Social Affairs, Popula0on Division, World Popula0on Prospects, 2005
The Longevity/Dementia Vicious Circle • Main risk factor for • World population dementia: age is aging • Incidence • Even more for the increases with age oldest
World Dementia Council Leading the Global Action Against Dementia
I can think of no other condition that has such a profound effect on loss of function, loss of independence, and the need for care. I can think of no other condition that places such a heavy burden on society, families, communities, and economies. I can think of no other condition where innovation, including breakthrough discoveries, is so badly needed. G8 Dementia Summit, London, 2013
The Political Push In Dec 2013, UK hosted a G8 • Dementia Summit Goal was to bring together • experts across the world to start a global conversation about solutions for dementia The Summit resulted in a • declaration that set out an international response to dementia with the aim of identifying a cure or a disease modifying therapy by 2025 France’s President Sarkozy had • put Alzheimer as a national priority in 2008 and lead a European rally around collaborative research at the origin of JPND World Dementia Council Leading the Global Action Against Dementia
The Initial World Dementia Council In February 2014, the UK Prime Minister appointed Dr • Dennis Gillings as the World Dementia Envoy & established the World Dementia Council (WDC) WDC Members are from a wide range of experts from • research, academia, industry, the NGO sector, people living with dementia & governments World Dementia World Demen0a Council Full Members, February 2016 Council Leading the Global Action Against Dementia
G7 to Global – The Continuity Model • Following the WHO First Ministerial conference in March 2015 a broad consensus was reached amongst key global stakeholders & the WDC, on a global model to pursue with the challenge of dementia • A complementary approach: Ø WHO working with Member States towards Ø Establishment of a Global Dementia Observatory Ø Preparation of a Global Action Plan on Dementia Ø WDC working with leaders from all sectors as well as PLWD, focused on 5 priorities and independent of governments Ø No formal governance between WDC and WHO, nor any other stakeholders, but a collaborative approach to optimize global impact World Dementia Council Leading the Global Action Against Dementia
The Current World Dementia Council • Since February 2016, WDC membership has been expanded globally – New members drawn from a range of sectors & organisations across the wider global dementia community (24 Members) – Chair/Vice-Chair – Yves Joanette/Raj Long World Dementia Council Leading the Global Action Against Dementia
Neurodegenerative Diseases Causing Dementia: A Life Course Challenge Prevent Cure/Delay Care Sperling et al., Alzheimer’s & Demen0a, 2011 Adapted from Jack et al., Lancet Neurol., 2010
Current Priorities of the Council 1. Favor integrated drug development 2. Advocate for innovative and global finance models 3. Encourage open science collaborative global research including big data 4. Stimulate adequate care for people living with dementia and their carers in high, middle and low-income countries 5. Facilitate the identification and the dissemination of risk reduction strategies Integrating cross-cutting themes § Women and dementia § Awareness § Stigma § Inequalities World Dementia Council Leading the Global Action Against Dementia
Finance Models Global Lead Chris Llewellynn Partner, McKinsey & Company, London • Design and promote a funding dashboard using exis0ng data to show current funding across the spectrum of demen0a-related ac0vi0es and to highlight dispari0es and cri0cal gaps • Iden0fy exis0ng/innova0ve alterna0ve funding models and approaches that could be applied to demen0a, e.g. Cancer, HIV etc. • Use the dashboard and data on funding models in order to reduce/eliminate funding dispari0es by influencing funder decisions World Dementia Council Leading the Global Action Against Dementia
Global costs of dementia will reach US$ 2 trillion by 2030 more than the costs of cancer and diabetes combined Global costs of disease Direct and indirect costs 1 , US $, billions Global costs, 2010 Global costs, 2030 % increase 2010-2030 290 The global cost of Cancer demen:a by 2030 +58% 458 will exceed: 863 Cardiovascular Current GDP of • +21% all but the 7 disease 1,040 wealthiest countries in the 500 world 2 Diabetes +49% 745 Two thirds of • the current 604 healthcare +231% Demen0a expenditure in 2,000 the US World Dementia 16 Council Leading the Global Action Against Dementia
But far less is spent on public sector demen:a research than on other major diseases % total research spend Cancer 6.8% Research spend per disease as a CVD 1 3.6% % of total research spend Diabetes 2.6% Demen0a 1.4% Research spend per prevalent case Less is spent on Cancer 2 3.7% demen:a Research spend research than CVD 1 N/A on disease per prevalent case on other major Diabetes 0.1% diseases Demen0a 0.5% Research spend for $ spent on health and social care Cancer 4.1% Research spend on disease per CVD 1 0.7% $ spent on care Diabetes 0.9% Demen0a 0.4% World Dementia Council Leading the Global Action Against Dementia
And only 2% of drugs in phase I-III development are focused on dementia Percentage of drugs in phase I-III development by therapeu:c area %, Extracted November 2014 and February 2015 Cancer 28% Cardiovascular 5% Diabetes 3% Demen0a 2% World Dementia Council Leading the Global Action Against Dementia
Progress – Finance Models • In March 2015, the WDC helped to shape the UK Govt-led work to establish the Dementia Discovery Fund – a ground breaking public/ private venture capital fund which aims to finance pre-clinical research to find new drugs to treat dementia. The initial fund level is just over $100m & it aims to raise a further $100m during 2016 World Dementia 19 Council Leading the Global Action Against Dementia
Integrated Drug Development Global Lead Raj Long Deputy Director, Bill & Melinda Gates Foundation • Iden0fy and engage key payer groups for medicines/ health technologies in Europe and globally, e.g. Na0onal Ins0tute for Health Clinical Excellence (NICE) in the UK • Develop a robust strategy for engaging payer groups, taking into account different models that exist (e.g. varying guidelines, expecta0ons etc.) • Iden0fy strategic drivers to enable the development of a global plan for access to demen0a treatments and to support adop0on of the plan World Dementia Council Leading the Global Action Against Dementia
Integrated Drug Development Currently focusing on areas of added values • Raj Long involved in IMI Roadmap Inititaive • WDC Associate Member States to facilitate connection with Health Technology Assesment • George Vradenburgh involved for US/ Canada World Dementia Council Leading the Global Action Against Dementia
Research, Open Science and Big Data Global Lead Philippe Amouyel Directeur général, Fondation Plan Alzheimer Scientific Director, JPND • Facilitate the global expansion of funding programmes such as the EU Joint Programme in Neurodegenera0ve Diseases • Develop a global statement promo0ng open science • Promote the use of big databases to public and private payers • Convene stakeholders to advocate for increased collabora0on in demen0a research and to address barriers • Influence Governments to invest in public interven0on trials to demonstrate the benefits of risk reduc0on World Dementia Council Leading the Global Action Against Dementia
Research, Open Science and Big Data • Facilitate the global expansion of funding programmes such as the EU Joint Programme in Neurodegenera0ve Diseases (Montreal, October 2016) World Dementia Council Leading the Global Action Against Dementia
Research, Open Science and Big Data • Facilitate the global expansion of funding programmes such as the EU Joint Programme in Neurodegenera0ve Diseases (Montreal, October 2016) • Develop a global statement promo0ng open science • Promote the use of big databases to public and private payers • Convene stakeholders to advocate for increased collabora0on in demen0a research and to address barriers • Influence Governments to invest in public interven0on trials to demonstrate the benefits of risk reduc0on World Dementia Council Leading the Global Action Against Dementia
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